MONOCLONAL CD43

Code: 143R-14 D2-231

General description

CD43, also called leukosialin, is expressed on the surface of all leukocytes except for some resting B-cells. It appears to function as an anti-adhesion m...


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€394.60 EACH
€485.36 inc. VAT

General description

CD43, also called leukosialin, is expressed on the surface of all leukocytes except for some resting B-cells. It appears to function as an anti-adhesion molecule, mediating repulsion amongst leukocytes. CD43 expression in lymphomas is highly correlated with CD5; thus most T-cell malignancies and a group of small lymphocyte B-cell malignancies [CLL/ SLL, mantle cell lymphoma (MCL), prolymphocytic leukemia] are often positive, while follicular lymphoma (FL) is usually negative. Anti-CD43 is less useful as a lineage marker, but is a sensitive indicator of aberrant B-cell populations. From 70 to 90% of T-cell lymphomas are labeled with this antibody. Plasmacytoma/myeloma and mast cell disease are also labeled with this antibody. No reactivity has been observed with reactive B-cells.

Linkage

CD43 Positive Control Slides, Product No. 143S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide

Preparation Note

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Quality

IVDIVDIVDRUO

antibody formculture supernatant
antibody product typeprimary antibodies
biological sourcerabbit
cloneSP55, monoclonal
conjugateunconjugated
controltonsil
descriptionFor In Vitro Diagnostic Use in Select Regions (See Chart)
formbuffered aqueous solution
Gene Informationhuman ... SPN(6693)
isotypeIgG1
packagingbottle of 1.0 mL predilute (143R-17), vial of 0.1 mL concentrate (143R-14), vial of 0.5 mL concentrate (143R-15), bottle of 7.0 mL predilute (143R-18), vial of 1.0 mL concentrate (143R-16)
Quality Level500
shipped inwet ice
species reactivityhuman
storage temp.2-8°C
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
visualizationmembranous
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